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Should you test positive for this gene variation, and find that you do indeed have issues relating to methylation, I recommend taking Rootcology MTHFR Pathways , as it contains ingredients (riboflavin, B6, methyl folate, B12, trimethylglycine, and L-serine) that support the metabolism of homocysteine and help maintain healthy homocysteine levels.* In my 2015 survey, 45 percent of people with Hashimotos said they felt better after adding methylation-supporting supplements to their regimen