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However, if they become persistent and start to affect your sleep, mood, or daily activities, its important to seek medical advice

The precise step sizes and timings varied by protocol arm

A mild warming or tingling sensation is normal after application

These include: Pre-existing constipation or slow transit constipation Inadequate dietary fibre intake Insufficient fluid consumption Reduced physical activity levels Concurrent medications with constipating effects (such as opioids, certain antidepressants, or iron supplements) Older age , where baseline colonic motility may already be reduced The severity of constipation often correlates with the dose of medication and may be more pronounced during dose escalation phases