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At the highest tested dose of 12mg administered once weekly, participants lost an average of 24.2% of their body weight
The Dulaglutide mechanism of action is the same as any other GLP-1 receptor agonists mechanism of action mimicking the naturally occurring GLP-1 hormone, limiting blood sugar levels, preventing excessive glucose production, and promoting satiety
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Purified complex (3 L, ~4 mg/mL) was applied to the grids that were subsequently vitrified in liquid ethane using Vitrobot Mark IV (Thermo Fisher Scientific) under 100% humidity at 4 C
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