Glutathione primarily functions as an antioxidant, helping protect cells from damage caused by external factors such as UV exposure, pollution, and stresskey contributors to dull and uneven skin tone (Dermatol Surg J, 2022)
It's essential to note that while BPC 157 has a high safety profile, with a very high LD50 indicating low acute toxicity, continuous or high-dose usage is not recommended without medical supervision
This is important because it lowers oxidative stress in the whole body (Scheen, 2020
You get both working without going from zero to nightly retinol
Add to this the complexity of modulation of topicals (skin irritation, skin threshold, cycling etc..The whole melasma treatment process can get very complex indeed, & that is before we even add any lasers or novel peels (of which there are over 20 methods in 5 to 10 settings or combinations)