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Retatrutide (Eli Lilly), a triagonist currently in phase III clinical trials (TRIUMPH-1 NCT05929066 and others 3 ) adds a glucagon receptor agonist to its mechanism of action, promising an even greater impact on weight loss

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In the central nervous system, GLP-1Rs are located in numerous regions and it is suggested that GLP-1RAs act to promote weight loss through distributed effects rather than a specific or localized response [41]

Patients with excess weight but not obesity might still meet the criteria if they have a related medical issue

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