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TLR2 pep-Cys was subsequently conjugated onto orid-liposome through reversible Michael addition reaction, through a cysteine residue between maleimide and thiol group

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However, patients with HCC often develop resistance to TKIs and this resistance development is associated with increased IGFBP-1 expression, the aggregation mechanism manifested by TKI-induced hypoxia increasing IGFBP-1 expression through activation of HIF-1 and HIF-2

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