It plays an important role in developmental biology, cellular communication, and growth-related signalling
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However, for optimal results, its generally recommended to combine their use with a balanced diet and regular exercise
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Additionally, it has been described that estrogens can regulate the differentiation of endothelial progenitor cells derived from bone marrow through mechanisms that include an increase in Akt phosphorylation and modulation of the telomerase activity, which consequently delays the onset of senescence (Imanishi et al., 2005)