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Despite the robust body of evidence showing the cardiovascular benefits of GLP-1 RAs, their origins as diabetes/glucose medications and the mode of administration of all but one by subcutaneous injection have posed barriers for cardiologists to adopt them as a routine part of clinical practice

A patient and clinician can start it today if it is appropriate and coverage allows

For injectable forms, some patients experience fewer side effects with evening administration

These lower prices would make the discussion below less important

Some classes of drugs have been removed only years after introduction into the market