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Kelly JG et al

This increase in ECM proteins fibrosis separates the individual bundles of muscle cells and disturbs the impulse propagation that causes the heart to beat regularly.[ref] Animal studies from about a decade ago show a pressure overload in the heart (stressing out the heart) can cause mast cells to proliferate

In summary, BPC-157 stands out among other peptides for its robust effects on tissue repair and inflammation in animal studies, but its long-term safety and efficacy in humans remain to be fully established

These requirements result in higher compliance costs and sometimes lead to market entry delays or restrictions for smaller manufacturers

Cartilage is, of course, among the slowest tissues to heal, so this application is important