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With 2.5mL or 5mL of water, the 1.7mg and 2.4mg doses require drawing volumes that exceed a standard 100-unit (1mL) syringe

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Panel B of Figure 5 shows that the fluctuations in methionine input cause very large fluctuations in SAM but only modest fluctuations in intracellular methionine concentration, as suggested by the early methionine loading experiments of Finkelstein and co-workers [53, 54]

doi: 10.1007/s13224-019-01251-1 87 CalogeroAGulloGLa VigneraSCondorelliRVaiarelliA

The production of both compounds is intricately linked