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Other Glutathione Side Effects (in All Forms) Here are some other adverse effects of glutathione that you should know about, no matter how you take it: Bloating or cramping in the stomach (when taken by mouth) Headaches and tiredness, especially during detox periods Hormonal imbalance (rare, but possible because to the livers load) Higher chance of not getting enough zinc (glutathione may make it harder to absorb) Who Should Not Take Glutathione