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The kinase activity of LRRK2 is responsible for phosphorylation of a subset of Rab small GTPase (Steger et al., 2016), which are important for exocytosis of synaptic vesicles, and endolysosomal and Golgi apparatus protein sorting (Bae and Lee, 2020)
When the peptide binds to these receptors, it initiates a signaling cascade that increases the expression of lipolytic enzymes, particularly hormone-sensitive lipase, which breaks down stored triglycerides into free fatty acids and glycerol
A person with Crohns disease may have trouble absorbing certain vitamins, such as vitamin B12, if they have undergone the removal of part or all of the ileum or if the disease affects their ileum
Observations from research literature are presented for experimental context only and do not imply approved human or animal use
doi: 10.1038/srep22155 214 PolishchukE
