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The weight-lowering effects of GLP-1 RAs are mediated through multiple, interrelated mechanisms
66 In a randomized, controlled phase 3 study by Jastreboff et al, no difference in gallbladder stone rates was observed between 5, 10, and 15 mg tirzepatide treatment and placebo in obese individuals over 72 weeks
Whilst mild to moderate fatigue during the initial weeks of tirzepatide treatment is relatively common and often self-limiting, certain presentations warrant prompt medical evaluation
Key Takeaways A recent NAD decision underscores that advertising compounded drugs in a way that implies they share the benefits of FDA-approved medications will likely be deemed deceptive by regulators
doi: 10.1007/s00464-021-08329-w
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