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Direct injection of bone marrow derived stem cells into the frontal motor cortex (a brain region) of human ALS patients is generally safe and well tolerated (Martinez 2012)
This systems-level activity has made it an important model for studies of skin physiology, connective tissue biology and regenerative signalling
Synovial Fibroblast-Derived Exosomal microRNA-106b Suppresses Chondrocyte Proliferation and Migration in Rheumatoid Arthritis via Down-Regulation of PDK4
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Laboratory studies use these receptor systems to investigate peptide mediated signaling pathways involved in neuroendocrine communication, nutrient sensing, and metabolic regulation within experimental models
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