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Regardless of ejection fraction, CF is an essential event in the transition of cardiac function from compensatory to decompensated period and represents one of the significant factors contributing to mortality in patients with heart failure ( 2.3.1 NF-B NF-B can participate in the occurrence and development of pathological cardiac remodeling by regulating the synthesis and release of ECM, cytokines, and chemokines (Wei et al., 2013