In 2020, the same team further reported that a higher dose (3200 mg/day) failed to improve depression beyond placebo effects, but side effects including abdominal discomfort (31%) and fluid retention (25%) became significantly more common 19
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Am J Physiol Endocrinol Metab 273: E981-988, 1997
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doi: 10.1111/imj.13104 [PubMed] 28489461 Levine M, Stellpflug S, Pizon AF, Traub S, Vohra R, Wiegand T, Traub N, Tashman D, Desai S, Chang J, Nathwani D, Thomas S