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Interestingly, HGF also reduces a caspase-independent ischemic neuronal cell death by preventing apoptosis-inducing factor (AIF) translocation downstream of poly(ADP-ribose)polymerase 1 (PARP1) and p53 (Cregan et al., 2004
doi: 10.1016/j.intimp.2023.110503 102 ZhaoC
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Research demonstrates that Dihexa induces hippocampal spinogenesis with potency comparable to HGF itself, significantly increasing the number of dendritic spines per unit length of dendrite in both dissociated neuronal cultures and organotypic hippocampal slice preparations
Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
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