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It often coexists with POTS and shares mechanisms like mitochondrial dysfunction, systemic inflammation, and oxidative stress

The brain needs glutathione to function well, and diseases like Alzheimer's and Parkinson's result in lower levels of this substance

doi:10.1111/dom.14863

People with methionine deficiency may have poor detoxification of xenobiotics and sulfhydryl reactive metals (mercury, lead, arsenic, and cadmium), or present with fatty liver or biliary insufficiency occlusive arterial disease