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Lut attenuates the levels of inflammatory cytokines and reduces oxidative stress in the kidneys of mice with IgAN As shown in Figure 2D, the secretion of TNF-, IL-1, and IL-6 was markedly increased in IgAN mice, whereas Lut treatment significantly reduced the levels of these proinflammatory cytokines compared with those in the IgAN group

It also strengthens the strands and prevents them from becoming weak or brittle

Research indicates that M2 macrophage-derived growth differentiation factor 15 confers ferroptosis resistance in the tumor microenvironment, identifying a key drug resistance mechanism (167)

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