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Histone-related genes include Hist1h2ai, H2afx, H3f3b 53

By utilizing biocompatible and highly hydrophilic modifying groups, such as polyethylene glycol (PEG), hyaluronic acid (HA), and polyamine compounds (like polyethyleneimine, PEI), nanoparticles can increase the binding ability with glycoproteins on the bladder mucosal surface, prolonging the drug retention time in the bladder and reducing drug loss due to urine flushing

There are certain other reasons as well, like Use of drugs like minocycline, birth control pills, certain cancer chemotherapies, etc

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Synonyms include GHK-Cu and glycyl-L-histidyl-L-lysine copper(II)