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Zhu Q, Zhuang XX, Chen JY, Yuan NN, Chen Y, Cai CZ, Tan JQ, Su HX, Lu JH (2021) Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models
T-4 is the parent compound
Mechanistic underpinnings center on collagen/elastin/GAG upregulation and antioxidant signaling described above
When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells
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