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However, multiple factors, including inflammation (Ahmad et al., 2022) and cerebral perfusion (Wolters et al., 2017) have been supported as early-stage biomarkers for neurodegenerative processes that are receptive to intervention prior to onset of clinically relevant loss in brain function

Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM: A Mathematical Model Gives Insights into Nutritional and Genetic Aspects of Folate-Mediated One-Carbon Metabolism

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Gluteq sublingual oral spray eliminates the first-pass effect of the liver, has better bioavailability, hence higher efficacy