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Strategies to manage them include starting with a low dose and gradually increasing, eating smaller, more frequent meals, avoiding fatty foods, and staying well-hydrated

Beginning below the usual initiation threshold and gradually increasing the dose may help the body adjust more comfortably

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In preclinical models and early human data, it has been hypothesised that the additional glucagon receptor activity may contribute to increased energy expenditure and broader metabolic effects

From a research perspective, these factors help explain why some participants tolerated 12 mg weekly with strong outcomes while others did better at 4 mg or 8 mg