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4.1 Increased BAX/Bcl-X L ratio, BAD, phosphorylated ERK, mitochondrial dysfunction and cellular stress in human epileptic brain tissues linked to CYP-mediated drug interactions We identified that patients taking a combination of multiple ASMs with varying CYP involvementNON-CYP + CYP substrate, NON-CYP + CYP inducer, CYP substrate + CYP substrate and CYP substrate + CYP inducershowed differential effects on the ratio of pro-apoptotic (e.g., BAX) and anti-apoptotic (e.g., Bcl-X L ) proteins in the epileptic brain tissues