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Gupta NA, Mells J, Dunham RM, et al

Thyroid concerns: Animal studies showed thyroid tumors with both medications

Data (Animal) In a combined fertility and embryofetal development study in rats, subcutaneous doses of 0.01, 0.03 and 0.09 mg/kg/day (0.1-, 0.4-, and 1.1-fold the MRHD) were administered to males for 4 weeks prior to and throughout mating and to females for 2 weeks prior to mating, and throughout organogenesis to Gestation Day 17

But anecdotally, shed heard that the supplement might help mitigate symptoms

Manufacturer labels often list 28 days, but real-world community use shows the peptide and the preservative both hold up well past that with clean handling and proper storage