Three isoforms of SOD exist in human body: the cytosolic Cu-, Zn-SOD (SOD1), the mitochondrial Mn-SOD (SOD2) and the extracellular Cu-, Zn-SOD (SOD3) 566
The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize
Similarly, chelating agents like EDTA can bind copper ions, reducing the peptides efficacy
Fifty percent of patients dont even recall having had a tick bite
inducible NOS (also known as iNOS, type II, NOS-II, and NOS2), being the isoform which can be synthesized following induction by pro-inflammatory cytokines or endotoxin and endothelial NOS (also known as eNOS, type III, NOS-III, and NOS-3), being the isoform expressed in endothelial cells (Murphy et al., 1993