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Risk of an infeasible or underpowered trial Given the aforementioned logistical, ethical and financial issues, a 2-arm RCT comparing the use of GLP-1 drugs for cancer prevention may not be feasible in the real world

While tirzepatide has shown strong results for both blood sugar control and weight loss, it can cause side effects

Many people notice changes within the first few weeks, but full appetite suppression often develops over 816 weeks as the dose increases

We don't, again, want that close effect and then no further weight loss

Without deliberate structure around protein , hydration , movement , and timing , the same drug that produces dramatic results can trigger muscle loss , fatigue , or side effects that halt progress