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Similarly in the mouse, global knockout of igf-1 results in a dwarfism phenotype, higher trabecular BV/TV (bone volume per tissue volume), a hypomineralized skeleton and growth plate defects characterized by reduced chondrocyte proliferation and differentiation and increased chondrocyte apoptosis (Wang et al., 2006b)
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Tonum cites human clinical trial data reporting about a 10.4% average weight loss over six months and notes that most of the loss was fat rather than lean mass
EC 50 : 2.6 nM5 nM)
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