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Mega C, Teixeira de Lemos E, Vala H, et al
The immunoblotting and immunofluorescence microscopy detection demonstrated that only GSTP-S184D entered the nucleus in LPS-untreated RAW264.7 cells, and LPS triggered GSTP (WT) but not GSTP-S184A to enter the nucleus (Figures 5B,C)
Similarly, levothyroxine (thyroid hormone replacement) and lisinopril (an ACE inhibitor for hypertension) regularly appear in the top 5
Mechanistic investigations revealed OBBs dual regulatory capacity: (i) AMPK hyperphosphorylation-mediated bioenergetic enhancement through UCP1 upregulation, and (ii) inflammation resolution via inhibiting aberrant phosphorylation of IRS-1 coupled with coordinated modulation of immunometabolic signalingsuppressing proinflammatory mediators (MCP-1, CD68, Nos2, CD11c) while activating the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3/GSK-3) [215]
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