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PIONEER 1 compared oral semaglutide with placebo [76], while PIONEER 24 compared oral semaglutide with the SGLT2i empagliflozin (25 mg once daily), the DPP-4 inhibitor sitagliptin (100 mg once daily), and the subcutaneous GLP-1RA liraglutide (1.8 mg once daily) [38, 39, 61, 62]
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They are usually mild and tend to improve over time
Micah Eimer, a clinical assistant professor at Northwestern Medicine and senior author of the study, said the research was inspired by a pattern he noticed among patients taking GLP-1 medications
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