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-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia
building the habit of consistent daily intake is the key focus
An animal study in rats has confirmed that a continuous decrease in IGF-1 results in cartilage damage [14]
Chronic inflammation is probably the biggest driver, whether from gut infections like SIBO or candida, autoimmune conditions, or persistent immune activation
it fundamentally changes the biological environment to allow for true, intrinsic repair
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