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Its mechanism involves specific engagement of AMY1R and AMY3R in hindbrain and hypothalamic circuits that regulate energy homeostasis, leading to preferential fat mass reduction and altered hypothalamic gene expression profiles [2]
Dungan KM, Povedano ST, Forst T et al (2014) Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
Research also indicates that tri-agonist signaling can influence adipose tissue distribution and body composition parameters measured in clinical and experimental settings
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Twice-weekly protocols balance convenience with more stable glutathione availability, representing a common middle ground for maintenance therapy
