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In the large semaglutide and tirzepatide obesity trials led by Wilding (2021) and Jastreboff (2022), gastrointestinal symptoms were the most common side effects, were generally mild to moderate, clustered around the dose-escalation phase, and eased over time for most people
While these findings dont directly translate to humans, they raise legitimate concerns about reproductive health, endocrine disruption, and metabolic stress with prolonged, high-dose usage
SEE HOW SEMAGLUTIDE CAN HELP YOUR WEIGHT LOSS JOURNEY Quick Answer: How Long Do You Stay on Semaglutide for Weight Loss
It is worth noting that the intensity of these gastrointestinal effects is often dose-dependent
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