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In the early 1900s, with the advent of new medical therapies and disease perspectives, novel strategies were employed to promote weight loss including thyroid hormone supplementation, and later, amphetamines [1]
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These numbers should be interpreted cautiously given the different trial designs, but the trend is consistent across multiple analyses
GLP-1 receptor agonists were originally developed to treat type 2 diabetes, with weight loss emerging as a secondary effect that later became its own use
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