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Even companies like Amgen and Novartis, still in early or limited stages in this space, are investing heavily in metabolic disease pipelines, signaling that the race for dominance in obesity and diabetes therapeutics is far from over and will only intensify as global prevalence of these conditions continues to rise

This creates a cycle where treating one condition can worsen the other

National Engineering Laboratory for Internet Medical System and Application open fund project (NELIMSA2018P03)

In the large intestine, the gut microbiota uses undigested dietary nutrients, fiber, and bile acids to produce metabolites such as SCFAs, indoles, and BAs, which induce further secretion of GLP-1 from ELs [13]