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This experimental knockdown triggered profound energy metabolic collapse: glycolysis and oxidative phosphorylation are impaired via dysregulated PI3K/AKT/mTOR and HIF-1/c-Myc signaling

Many people with obesity, prediabetes, or metabolic syndrome develop elevated triglycerides without realizing it, since high triglycerides rarely cause noticeable symptoms

Studies with longer follow-up duration are required to further investigate the potential factors associated with weight change after discontinuation of treatment

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