All applications are restricted to non-clinical experimental contexts
Prior to the weighting of covariates, GLP-1 receptor agonist users were more likely to be obese, diagnosed with T2D for a longer duration, and female as compared to those prescribed SGLT-2 inhibitors
5 Reactive oxygen species as oxidizing agents: impact on cysteine proteinases and cellular homeostasis It has long been established that disturbances in reactive oxygen species (ROS) regulation generate highly reactive cellular environments, profoundly influencing intracellular signaling pathways and contributing to oxidative stress
Of the two clinical trials that featured in the study, a 26week trial of liraglutide found no reduction in amyloid levels or cognitive improvement, but did show preservation of brain glucose metabolism, an indicator of neuronal function
Raw data for statistical analyses and supplemental data are available at Zenodo (DOI: 10.5281/zenodo.14916225) Ethics statement The animal study was approved by Lower Saxony State Office for Consumer Protection and Food Safety (LAVES, Oldenburg, Germany)