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Increasing protein intake to 1.6g per kilogram of goal body weight often reverses early muscle loss signs

This extended duration supports once-weekly dosing, ensures steady receptor engagement, and provides consistent weight loss effects without major fluctuations in hunger or glycemic control

The cost is a real chronic-exposure burden on the myocardium, but it is small in energetic terms the entire resting myocardium consumes only about 170210 kcal/day, so a 1 bpm rise on a base of 70 represents roughly 1.4% of that, on the order of 23 kcal/day

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Papadopoulou MT, Dalpa E, Portokalas M, Katsanika I, Tirothoulaki K, Spilioti M, et al