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The study is estimated to last until accrual of a pre-specified number of events of interest: all-cause mortality, cirrhosis development, and liver-related clinical outcomes (estimated duration four years of treatment).92 Cenicriviroc Cenicriviroc (CVC) is a dual CCR2/CCR5 chemokine receptor antagonist that has been shown to play key roles in hepatic inflammation and fibrosis.[93], [94] In the setting of hepatocyte injury, kupffer cells secrete C-C chemokine ligand type 2 (CCL2) triggering CCR2 receptors to initiate an inflammatory response

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