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When combined with the potential side effects of GLP-1 or GIP medications, this can be uncomfortable

Use With Extreme Caution or After Discussion With Your Doctor: History of severe GI problems: Such as gastroparesis (delayed stomach emptying) or severe inflammatory bowel disease

Conversely, fatigue is a recognized side effect, particularly during initial treatment

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For example, in obese diabetic mice fed a methionine and choline-deficient diet (MCD), an FGF21 analog significantly reduces fibrogenic expression and inhibits hepatic fibrosis (152)