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Government support programs: The Pharmaceutical Benefits Advisory Committee (PBAC) estimates that subsidising semaglutide for obesity would cost over $1 billion annually over a six-year period

We dont fully understand this yet, but it is important to keep in mind when considering weight loss distribution in shorter trials and especially when drawing conclusions at early timepoints

The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)

This same dopamine shift can make food and other reward-driven behaviors feel less satisfying, which some users experience as a temporary muted feeling