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7-Keto-cholesterol and cholestan-3beta, 5alpha, 6beta-triol induce eryptosis through distinct pathways leading to NADPH oxidase and nitric oxide synthase activation

Cells were then lysed in 0.1 M NaOH, and radioactivity determined by -counting as described previously 47

The high ROS environment lowers the activation threshold of mast cells, causing them to degranulate inappropriately and release a flood of inflammatory cytokines, including histamine, interleukins, and tumor necrosis factor-alpha (TNF-a)

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As a consequence of high levels relative to other organs, ALT is considered more specific to the liver than AST