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Retatrutide adds a third receptor target the glucagon receptor making it a triple agonist
While it activates the GLP-1 receptor, Zepbound also targets the GIP (glucose-dependent insulinotropic polypeptide) receptor, making it a dual receptor agonist
Although this is perhaps slightly behind retatrutide at this early time point
The primary outcome was clinically significant residual gastric volume as observed during EGD
2026 Study Reveals All
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