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The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)
Hum Mutat
Additionally, in another Phase II study targeting patients with T2DM, orforglipron also showed significant effects in reducing A1C and weight, achieving the studys primary and secondary endpoints
The real question is whether this space will mature into a legitimate, responsible arm of obesity medicine or be dismissed as a chaotic market of pill mills
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