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For superoxide anion, the main ROS, a first line of defense is represented by the enzyme superoxide dismutase, localized in the mitochondrial matrix

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Similarly, an increasing number of studies have found that ferroptosis can also be regulated in the process of epigenetics, including histone PTMs, DNA methylation, non-coding RNA regulation, and PTMs[5]

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Finally, the model predicts that p62 knock-down by siSQSTM1 yields lower base levels of Keap1-GFP in the autophagosome and also lower levels upon DEM treatment relative to the siCtrl condition (Fig 3C