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Wang Y, Chen D, Xie H, Jia M, Sun X, Peng F

In a rat model of DOCA-salt hypertension, vascular mitochondrial ROS production was markedly elevated, accompanied by the activation of other ROS sources

It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients

Cell Metabolism , 37 (8), 17321749.e9

It far outperforms the pill form