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9,10 Generally, rats, mice, guinea pigs, rabbits, and other animals can be used as animal models to evaluate candidate vaccines immunogenicity, tolerance, and safety

For example, in certain neurodegenerative diseases, modulating SIRT3 activity can help manage mitochondrial dysfunction and oxidative stress 182

This is good practice when starting any new medication, not something specific to semaglutide

More recently, the FDA approved it to reduce the risk of kidney failure and heart-related death in adults with comorbidities like type 2 diabetes and chronic kidney disease