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In dermal fibroblast cultures, GHK-Cu has been shown to stimulate procollagen, glycosaminoglycan, and decorin synthesis, and has been characterized for antioxidant and anti-inflammatory effects in neuronal and macrophage cell models

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It has been proposed that epithelial and mesenchymal cells survival relies on the signaling provided by integrins attached to a rigid surface and that culturing them in 3D gels leads to cell death by preventing attachment to a rigid surface [26]

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Clinical observations report density increases of 20 to 30 percent after three to six months of consistent topical use