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GLP-1 drugs like Ozempic might have started out as Type 2 diabetes medications, but their weight loss potential is what thrust them into the national spotlight
A meta-regression study suggested a linear relationship between HbA1c reduction and MACE risk in patient with arGLP-1.89 Publication on mediation analyses also suggest that cardiovascular benefit could be mediated in part by effects on HbA1c, on blood pressure or reduction in urine albumin-creatinine ratio90,91 (see below), as well as by their effect on lipid profile.81 However, in subgroup analyses of cardiovascular safety studies, baseline HbA1c, weight, previous cardiovascular disease, or renal function did not predict the beneficial effects of these drugs on MACE,87 so other mechanisms, such as the previously mentioned anti-inflammatory, antifibrotic, antiatherogenic, vasodilator, or endothelial function-enhancing effects, have been suggested to influence the cardiovascular benefit of these drugs29,78 (Fig
10.1016/j.exer.2021.108624 25 GuttenplanK
cutting weight loss drug coverage, patients scramble to afford prescriptions Thousands of Massachusetts residents are on the verge of losing insurance coverage for powerful weight loss drugs that have helped them manage obesity when other treatments have failed
Documented Synergistic Effects in Preclinical Research Multiple research groups have documented synergistic GH release when combining GHRH with GHRPs across various experimental models
