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PMID: 30544065 ACS Omega 2025 Oct 17;10(42):50208-50217
Storage and Stability Keep lyophilised MOTS-c refrigerated (28C) After reconstitution, store in the fridge and use within 2128 days (depending on manufacturer instructions) Safety and Side Effects of MOTS-c Peptide Dosing MOTS-c is generally well-tolerated at recommended doses, but potential side effects include: Mild irritation at the injection site Headache or dizziness (rare) Nausea or gastrointestinal discomfort No long-term adverse effects have been reported in clinical trials at typical doses, but research is still limited
The peptide bond between histidine and D-2-naphthylalanine remains vulnerable to pepsin cleavage at pH 2.0, the typical gastric environment during fasted administration
Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway
For women, it supports a wide range of reproductive and sexual health functions, often quietly in the background
